The Anticancer Effect of Cannabinoid 2 Agonist L-759,633 on C6 and SH-SY5Y Cell Lines

Purpose: Previous studies have shown that cannabinoid 2 agonists anticancer effects on different cancer cell lines. However, the effect of L-759,633 C6 and SH-SY5Y lines is still unclear. The current study was designed to investigate potential cytotoxic a agonist Material Methods: In this study, were used. For each line two groups prepared examine glioma death. It not applied any treatment cells in control groups. Various concentrations (5, 10, 20, 40 80 μM) After 24 hours viability examined using XTT assay. Total oxidant status (TOS) antioxidant (TAS) measured by commercial kits. Results: at 5, μM significantly decreased (p 0.05). On other hand agent did reduce viability. Conclusion: has antiproliferative cells. Additionally, one mechanisms involved activation generation. However drug didn’t show cell. Keywords: L-759,633, Oxidative Stress, viability, Glioma,